The Endocannabinoid System – What You Should Know
Your endocannabinoid system is a complex network that regulates mood and inflammation, amongst other things.
Discovery of the Endocannabinoid System
In 1988, scientists made their first discovery of a cannabinoid receptor in the brain of a rat. This discovery was very significant in light research from by Israeli scientist Dr. Raphael Mechoulam. In 1964, Dr. Mechoulam became the first person to isolate and identify both THC and CBD from cannabis.
These two discoveries have allowed scientists to work towards a better understanding of the endocannabinoid system in humans and the way that the phytocannabinoids (cannabinoids derived from plants) THC and CBD, impact the receptors in our bodies and brains.
Humans actually produce similar substances naturally, known as endocannabinoids and these neurotransmitters perform a dazzling array of functions in our bodies.
Functions of the Endocannabinoid System
There are two main types of cannabinoid receptors, CB1 and CB2. CB1 receptors are mostly found in the brain, while CB2 receptors are primarily spread throughout the body.
In the brain, these CBD receptors exist with the highest concentration in the limbic system. The limbic system is not a separate part of the brain but is a collection of the hippocampus, hypothalamus, piriform cortex, amygdala, and more.
This crucial brain region is mostly responsible for emotion, mood, behavior, olfaction (smell), and memory. This may begin to explain why an underactive endocannabinoid system can increase anxiety, fear, and depression, while reducing the joy one may derive from food and sex.
When these systems are not functioning optimally, it can cause extreme stress in the body, a potential overproduction of cortisol (among other things), and host of complications which may include:
- Brain Fog
- Gastrointestinal Problems
- Underactive Thyroid
- Cold Hands and Feet
- Frequent Urination
- Weak Appetite
- Low Blood Pressure
Clinical Endocannabinoid Deficiency (CECD)
Clinical Endocannabinoid Deficiency is a condition where an individual has a lower amount of endogenous cannabinoids than experts consider necessary to promote health and well-being.
Scientists now believe CECD may play a role in the following conditions:
- Irritable Bowel Syndrome (IBS)
- Multiple Sclerosis (MS)
- Post-Traumatic Stress Disorder (PTSD)
- Motion Sickness
These conditions often require a significant amount of medications to manage and treat. And while those medications are helpful, some of them come with a pretty significant of potential side effects. This list includes things like nausea, vomiting, abdominal pain, weakness, numbness, insomnia, suicidal thoughts, depression, anxiety, breathing difficulties and in some cases, death. These side effects are not incredibly common but they do exist.
But, there is good news. Because CEDC is considered a factor in so many illnesses, researchers across the globe are currently conducting studies to see if using a substance like CBD oil to elevate the cannabinoids in the body can have a positive impact on some of these conditions, providing relief without so many dangerous side effects.
The Human Body Produces Cannabinoids?
Anandamide is a neurotransmitter known as ‘the bliss molecule’ (ananda is a Sanskrit word that roughly translates to bliss). Anandamide is actually an endocannabinoid. It is a type of endogenous cannabinoids.
There are actually three varieties of cannabinoids — endogenous cannabinoids, phytocannabinoids, and synthetic cannabinoids. Let’s take a closer look at each:
Endogenous Cannabinoids: These are neurotransmitters produced within our bodies that bind to cannabinoid receptors in the brain, immune system, and other tissues. Examples include anandamide, 2-arachidonoylglycerol (2-AG), n-arachidonoyl dopamine (NADA), and virodhamine (OAE).
Phytocannabinoids: Refers to chemicals found in plants that, to varying degrees, mimic the action of our endogenous cannabinoids. Plants containing cannabinoids include:
Additionally, scientists have successfully generated yeast (Pichia pastoris) that can synthesize THCA.
Synthetic Cannabinoids: Synthetic cannabinoids are essentially chemicals synthesized in laboratories, hopefully professional laboratories, that mimic our endocannabinoids. Most ‘synthnoids’ are named with an alphanumeric combination like JWH-007, JTE-907, or FAB-144.
Most health experts issue stern warnings about using synthetic cannabinoids, as studies link their usage to a myriad of long-lasting health problems.
Endocannabinoids perform in stark contrast to more well-known neurotransmitters such as serotonin, dopamine, and norepinephrine.
Dopamine, for example, is synthesized in advance, stored in the vesicle, and then released (in response to stimuli) from the presynaptic cell, where it crosses the synapse, lands on the postsynaptic cell, and causes activation.
Endocannabinoids, on the other hand, are integral components of cellular membranes that we appear to manufacture on demand. As they are hydrophobic, they cannot travel very far in the body and exert only local effects.
This limited effect makes endocannabinoids different from hormones, which are far-reaching and impact the entire body.
Additionally, endocannabinoids travel backward; first leaving the postsynaptic cell and ending at the presynaptic cell in areas where the axons are in high concentrations.
In essence, this allows the postsynaptic cell a sort of ‘flow control.’ This enables it to mitigate the flow of neurotransmitters coming from the presynaptic cell.
Anandamide is far and away the most widely researched endocannabinoid. It is an analog of THC and has a similar pharmacology, sharing roughly the same potency at the CB1 receptor.
It is synthesized in brain regions responsible for memory, motivation, and higher thought processes. Anandamide is crucial for :
- Immune Function
Anandamide has been found to reduce the proliferation of breast cancer cells, has anti-anxiety and anti-depressant effects, and increases neurogenesis. Anandamide also plays a significant role in memory formation and also is a factor in forgetting.
Anandamide, Exercise, and Going With the Flow
For quite some time, experts agreed that the world-renowned ‘runner’s high’ was due to the release of endorphins in the body after intense exercise.
However, in 2015, German researchers demonstrated that endorphin molecules are too large to pass the blood-brain barrier.
Through their experiment on mice, they concluded the mice’s ability to experience the runner’s high was mostly dependent on their cannabinoid receptors.
We all have experiences where we feel focused, happy and as though we are performing at our peak, which makes time feel like it’s just flying by.
This ‘flow state’ is the result of increased neurotransmitters, including anandamide.
Boosting Anandamide Levels With Food, ASA, and CBD Oil
A primary building block in the synthesis of anandamide is arachidonic acid (AA), a fatty acid found in various foods throughout nature. Primary sources include:
As with all bodily systems, diet and nutrition play a huge role in the healthy functioning of endocannabinoids. Individuals who consume plant-based diets, in particular, may have more difficulty with maintaining optimal anandamide levels.
Anandamide has a very short half-life (approximately 5 minutes) and is broken down by Fatty Acid Amide Hydrolase (FAAH).
Considering this, developing inhibitors of FAAH has become an area of much research.
CBD oil is considered a FAAH inhibitor. Other FAAH inhibitors include:
AM404 is the metabolic result of acetaminophen (Tylenol) combining with arachidonic acid (AA), and is also an agonist of both CB1 and CB2 receptors. This activity may explain the analgesic effects of acetaminophen.
While cacao has several known FAAH inhibitors, the stimulant theobromine contained in cacao that is thought to encourage the direct production of anandamide.
Anandamide, Pregnancy, Fertility, and Motherhood
The evidence points towards anandamide being the first line of communication between a mother and her unborn child. This particular endocannabinoid is vital for the healthy implantation of a young embryo in the wall of the uterus.
Researchers have further found that anandamide levels are highest during ovulation.
Interestingly, anandamide may also be a pivotal substance in triggering newborns to suckle at their mother's breast. When newborn mice received a potent CB1 receptor antagonist (SR141716A), the mice pups failed to latch at the mother’s breast and died within a week.
The central role endocannabinoids play in fertility, pregnancy, and infancy may mean significant dangers faced by expecting mothers who choose to use cannabis products.
As always, it is important to consult with your physician and raise any questions or concerns you may have regarding the use of a natural product like CBD.
Although the 2-AG endocannabinoid doesn’t receive the same praise or attention as amandamide, it has been shown to be present at concentrations 170x greater than anandamide. 2-AG plays a role in governing:
- Immune Function
- Bone Health
2-AG originates from arachidonic acid, EPA, and DGLA. Great foods to eat to increase the omega-6 building blocks for 2-AG include:
- Pasture Raised Eggs
Keep in mind that experts recommend consuming omega-6 fats alongside omega-3 in a 3:1 ratio. Unfortunately, most American diets see a consumption of omegas at a 20:1 ratio!
Anandamide is a selective partial agonist for the CB1 receptor, 2-AG is a full agonist of both the CB1 and CB2 receptors.
While FAAH plays a role in breaking down 2-AG, Monoacylglycerol Lipase (MAGL) metabolizes around 85% of all 2-AG. To date, the only MAGL inhibitor shown to increase 2-AG is JZL184.
However, knowing that 2-AG is the primary cannabinoid with activity at the CB2 receptor, increasing CB2 receptors could be useful.
The probiotics Lactobacillus acidophilus has been shown to increase CB2 receptors in the intestines.
While probiotics are always a good idea, prebiotics are an often overlooked solution to increase the health of our microbiome and the number of CB2 receptors.
Prebiotics are the food source for good bacteria. Food sources that provide a good amount of prebiotics include:
- Jerusalem Artichoke
- Leafy Greens
While THC has a strong binding affinity for both CB1 and CB2, cannabidiol (CBD) has little affinity for either receptor. Instead, CBD exhibits most of its natural benefits through indirect actions (or by activating non-cannabinoid receptors/ion channels) such as:
- Potentiating Glycine Receptors: Glycine receptors are the most widely distributed inhibitory receptor in the central nervous system, and plays a significant role in pain perception via the spinal cord and brainstem. CBD has been found to potentiate these receptors, generating excitement for its potential use treating chronic pain and inflammation. [S]
- Binding with the Dopamine D2 Receptor: Many commonly prescribed antipsychotic pharmaceutical drugs target this receptor, and this may help explain CBD’s potential benefit in managing schizophrenia. [S]
- Enhancing Adenosine Activity: CBD partially prevents the reuptake of adenosine, via inhibition of the equilibrative nucleoside transporter 1 (ENT1). This interaction with adenosine is thought to play a large role in CBD’s potential benefits for inflammation and autoimmune conditions. [S]
- Fatty Acid Amide Hydrolase (FAAH) Inhibition: This leads to higher levels of endocannabinoids such as anandamide. Endocannabinoids exhibit activity at CB1 and CB2 receptors, providing a myriad of natural benefits. [S]
- Activating PPAR-gamma Receptors: PPAR-gamma receptors are located on the cell’s nuclei and play a role in degrading beta-amyloid plaque, as well as lipid uptake, insulin sensitivity, and dopamine release. This action explains why CBD may have benefits with regards to diabetes, schizophrenia, and Alzheimer’s. [S]
- Antagonizing GPR55 Receptors: GPR55 receptors are widely distributed in the brain (especially the cerebellum) and help control bone density and blood pressure. Additionally, GPR55 promotes cancer cell proliferation when activated. These facts may explain CBD’s potential role in assisting with osteoporosis and high blood pressure. [S]
- Activates the 5-ht1A Receptor (at high doses): The 5-ht1a receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA (the raw form of CBD) shows an even higher affinity for this receptor than CBD. [S]
- Activating TRPV1 Receptors: Involved in regulating pain, body temperature, and inflammation. Other substances targeting TRPV1 receptors include anandamide, AM404 capsaicin, and various cannabinoids such as CBN, CBG, CBC, THCV, and CBDV.
- Being an Allosteric Modulator: Allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters fundamentally. CBD is an allosteric modulator of mu and delta opioid, CB1, 5-ht3A, GABA-A, and a7-AChR receptors – owing to a myriad of natural benefits from relief of depression to enhanced memory and learning abilities. [S], [S], [S], [S]
CBD Oil for Endocannabinoid System Health?
Cannabidiol is emerging as a promising natural supplement for a countless number of widespread health concerns, many of which are difficult to treat through allopathic medicine.
If you feel you are experiencing any or all of the symptoms of CECD, or are simply looking to increase your endocannabinoid levels, consider talking to your physician about CBD oil. Use this information as your starting point and do not be afraid to begin a real dialogue.
We know it is a challenge to wade through the medical and scientific information and we hope this gives you the confidence you need to find the best solutions for you and your lifestyle.
+ 60 sources
(2016) Timeline: Discovering the Endocannabinoid System - Hytiva
Anthony J. Ocon (2013) Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome - National Center for Biotechnology Information
Kelli Miller (2020) Hypothyroidism (Underactive Thyroid) - WebMD LLC
Ethan B. Russo (2016) Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes - National Center for Biotechnology Information
Anandamide - Wikipedia®
Sanskrit - Wikipedia®
Cannabinoid - Wikipedia®
2-Arachidonoylglycerol - Wikipedia®
N-Arachidonoyl dopamine - Wikipedia®
Virodhamine - Wikipedia®
Dr. Ananya Mandal (2019) Phytocannabinoids - AZoNetwork
Kava - Wikipedia®
Radula marginata - Wikipedia®
Helichrysum umbraculigerum - SA National Biodiversity Institute
Acmella oleracea - Wikipedia®
Echinacea - Wikipedia®
Theobroma cacao - Wikipedia®
Tuber melanosporum - Wikipedia®
Pichia pastoris - Wikipedia®
JWH-007 - Wikipedia®
JTE-907 - Wikipedia®
FAB-144 - Wikipedia®
Ziva D. Cooper (2016) Adverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and Withdrawal - National Center for Biotechnology Information
Vesicle (biology and chemistry) - Wikipedia®
(2018) Presynaptic and postsynaptic neurons - School of Biomedical Sciences Wiki
Luciano De Petrocellis et al. (1998) The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation - National Center for Biotechnology Information
Silvana Gaetani et al. Anandamide hydrolysis: a new target for anti-anxiety drugs? - National Library of Medicine
G. Gobbi et al. (2005) Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis - National Center for Biotechnology Information
Adult neurogenesis - Wikipedia®
E Murillo-Rodríguez et al. Anandamide modulates sleep and memory in rats - National Library of Medicine
Bradley E. Alger, Ph.D. (2013) Getting High on the Endocannabinoid System - National Center for Biotechnology Information
Johannes Fuss et al. (2015) A runner’s high depends on cannabinoid receptors in mice - National Academy of Sciences
Arachidonic acid - Wikipedia®
N-Acylethanolamine - Wikipedia®
Palmitoylethanolamide - Wikipedia®
Guineesine - Wikipedia®
Kaempferol - Wikipedia®
AM404 - Wikipedia®
Mona R El-Talatini et al. (2009) The relationship between plasma levels of the endocannabinoid, anandamide, sex steroids, and gonadotrophins during the menstrual cycle - National Library of Medicine
Rimonabant - Wikipedia®
R Mechoulam et al.(2006) Endocannabinoids, feeding and suckling – from our perspective - Springer Nature Limited
Patricia H. Reggio (2014) Endocannabinoid Binding to the Cannabinoid Receptors: What Is Known and What Remains Unknown - National Center for Biotechnology Information
Artemis P. Simopoulos (2016) An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity - National Center for Biotechnology Information
Monoacylglycerol lipase - Wikipedia®
Melinda M. Mulvihill et al. (2012) Therapeutic Potential of Monoacylglycerol Lipase Inhibitors - National Center for Biotechnology Information
JZL184 - Wikipedia®
Christel Rousseaux et al. (2006) Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors - National Library of Medicine
Binding affinity - Malvern Panalytical Ltd
Wei Xiong et al. (2012) Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors - National Library of Medicine
P Seeman (2016) Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose - National Center for Biotechnology Information
Esther M. Blessing et al. (2015) Cannabidiol as a Potential Treatment for Anxiety Disorders - National Center for Biotechnology Information
Clementino Ibeas Bih et al. (2015) Molecular Targets of Cannabidiol in Neurological Disorders - National Center for Biotechnology Information
Huizhi Du et al. Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ - National Library of Medicine
Haleli Sharir et al. (2010) Pharmacological Characterization of GPR55, A Putative Cannabinoid Receptor - National Center for Biotechnology Information
Ethan B Russo et al. Agonistic properties of cannabidiol at 5-HT1a receptors - National Library of Medicine
R B Laprairie et al. (2015) Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor - National Center for Biotechnology Information
Markus Kathmann et al. (2006) Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors - National Library of Medicine
Mohamed Mahgoub et al. (2013) Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors - National Library of Medicine
Laxmikant S Deshpande et al. (2011) Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons - National Library of Medicine
Learn More About CBD
CBD oil products are everywhere now, but ambiguity surrounding the use of CBD oil still abounds, especially in the world ...Learn More
Imagine this: you're curled up on your comfortable couch, surrounded by soft throw pillows, sipping a cup of hot chocolate ...Learn More
Though many people are still learning about cannabidiol (CBD) and its many natural benefits, the naturally occurring chemical compound has ...Learn More
A lot of people ask this question - is CBD oil legal in Florida? It appears that there has been ...Learn More
If you're just starting to learn about CBD and its potential benefits, you likely have many questions. There is so ...Learn More
Every plant on the planet has a purpose. Every piece of the ecosystem serves a purpose, and some lucky plants ...Learn More
For decades, people have been raving about the endless benefits of the hemp plant. Surprisingly though, some people may still ...Learn More
I’ve been poking around the interweb a bit for travelling with CBD tips and was a little surprised… I think ...Learn More
Delta 8 THC is the hot new cannabinoid on the wellness scene. As was the case with CBG a couple ...Learn More
The term ‘seed to sale’ is thrown around a lot in CBD marketing. CBD companies that claim to be seed ...Learn More
Delta 8 THC is one of the many cannabinoids found in the hemp plant. Like cannabidiol aka CBD oil, delta ...Learn More
We don’t have to tell you. You already know that CBD oil is one of the most important wellness discoveries ...Learn More
Hemp CBD has a confusing history of legalization that it shares with its intoxicating cousin, marijuana. Both the federal and ...Learn More
Like many people, it is likely that you have seen an increase in the popularity of CBD in the last ...Learn More
These days, it seems like everyone is talking about CBD oil and the benefits it can provide. Yet, if you ...Learn More
If you are interested in using CBD oil, but you live in Tennessee, you may have a lot of questions ...Learn More
Although the CBD industry continues to grow by leaps and bounds, many people interested in the cannabinoid's therapeutic potential are ...Learn More
If you live in Virginia, and you are interested in buying CBD oil, you may be wondering several things. For ...Learn More
CBD oil products have come to the forefront of discussions about non-traditional solutions to anxiety, pain, and other ailments that ...Learn More
CBD oil products have gained popularity in Michigan and across the nation because of the potential benefits they offer consumers ...Learn More
For fans of soccer (or football as most of the world calls it), there is likely a lot of speculation ...Learn More
A hemp flower is the most basic form of CBD and serves as the foundation for all other CBD products ...Learn More
The safety, legality, and absence of mind-altering properties make cannabidiol (CBD) a popular choice for those who want to reap ...Learn More
Between 2021 and 2027, the weight loss industry will benefit from a compound annual growth rate (CAGR) of 10.6%. As ...Learn More
If you live in Ohio and you are curious about using CBD, you may have a lot of questions. For ...Learn More
Cannabidiol (CBD) is one of more than 100 active compounds found in the cannabis plant. CBD oil manufacturers extract cannabidiol ...Learn More
If you were to ask a group of CBD enthusiasts for product recommendations, you'd soon discover that CBD users seem ...Learn More
In 2014, when the industry was still quite new, CBD generated nearly 50 million dollars in sales. That's pretty impressive ...Learn More
Industrial hemp was one of the very first domesticated crops, a plant harvested throughout history for its protein-rich seeds and ...Learn More
As you have likely heard by now, CBD has quickly become one of the biggest trends in the world of ...Learn More
Surprisingly enough, there are a lot of misconceptions floating around when it comes to cannabidiol. Cannabidiol, more commonly known as ...Learn More
CBD products are becoming increasingly popular in 2021, and CBD concentrates are no exception. If you've thought about trying CBD ...Learn More
Let's talk self care. Though you might think of self care as simply "pampering" yourself, it goes way deeper than ...Learn More
Texas Governor Abbott signed legislation clarifying which hemp products are legal and which are not. Looking for CBD in Texas? ...Learn More
CBD oil has many helpful-- not to mention, natural-- benefits physically and mentally. CBD has been heavily studied to relieve ...Learn More
If you are an avid runner, you are always looking for safe and healthy ways to improve your performance and ...Learn More
Can you use CBD if you are sober? Recovery from drug or alcohol addiction isn't just about abstinence. For many, ...Learn More
If there's anything we've learned from the last few years of incredible development, it's that the cannabis plant can take ...Learn More
By now, you are probably aware that there are a lot of CBD products on the market that can help ...Learn More
If you have never tried CBD oil and you live in Indiana, you probably have a lot of questions. You ...Learn More
CBD (short for cannabidiol) has become an alternative consideration for many parents around the world. Countless families swear by CBD ...Learn More
Birth control remains one of the greatest biomedical advances in the last century, giving women and couples the opportunity to ...Learn More
When shopping for CBD, it's essential to find the best product for your needs and your lifestyle. While CBD tinctures ...Learn More
For people who are considering CBD or have already started trying what is available, one of the most common questions ...Learn More
CBD oil is well known for its ability to regulate pain and inflammation, making it a valuable tool in the ...Learn More
Cannabinoid hyperemesis syndrome (CHS) is a true mystery. It can pop up out of nowhere for chronic cannabis users, and ...Learn More
When you first begin researching CBD oil, it can be hard to understand what you are reading. What exactly is ...Learn More
Death by overdose has become the largest killer of Americans under the age of 50, and with opioids responsible for ...Learn More
The most famous cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is most widely known for its mind-altering, high-inducing properties, ...Learn More
Because harvested and dried cannabis or hemp material only contains trace amounts of cannabigerol (CBG), it is often considered to ...Learn More
With cannabidiol (CBD) oil becoming more widely available, it is being sought out by an ever-growing number of people due ...Learn More
In 2018, the United States saw exponential growth in CBD oil product development and sales. Halfway through the year, the ...Learn More
The cannabis sativa plant contains hundreds of cannabinoids, each one presenting its own unique qualities and potential benefits. You may ...Learn More
Cannabinoids have taken over the natural health discussion, and with good reason. Research is continuously finding new ways in which ...Learn More
One of the lesser-known cannabinoids, cannabichromene (CBC) may be able to do some pretty incredible things. Recent scientific study has ...Learn More
Learning about the phytocannabinoids that exist in the cannabis plant family can feel a little bit like sifting through alphabet ...Learn More
Cannabidiol (CBD), is becoming widely used for its reported therapeutic benefits, which include pain reduction, nausea relief, and mood elevation ...Learn More
Tetrahydrocannabinol (THC) is probably the best-known cannabinoid found in the cannabis plant. THC is the psychoactive, intoxicating, and mind-altering compound ...Learn More
Of the many phytocannabinoids found in cannabis plants, tetrahydrocannabinol (THC) and cannabidiol (CBD) are likely the most well-known. That's why ...Learn More
The role of “Big Pharma” in healthcare is a contentious subject and one that’s working its way into discussions around ...Learn More
With more and more research coming out that shines a light on the reported health benefits of CBD and essential ...Learn More
Researchers are finding that CBD oil may be able to treat the symptoms of a whole host of diseases and ...Learn More
When you first decide to use CBD oil, it can be hard to know where to start. With so many ...Learn More
Health supplements are becoming increasingly commonplace as average Americans struggle to meet their recommended daily intake of vitamins and minerals ...Learn More
If you've spent any time reading about CBD oil and cannabis lately, it is likely you've seen terpenes mentioned more ...Learn More
If you’re interested in purchasing CBD oil but aren’t sure if it’s legal in your state, you’ve come to the ...Learn More
The CBD oil industry is one of the fastest-growing in North America and as such, it should come as no ...Learn More
Not long after the first cannabinoid was isolated from the cannabis plant, scientists discovered the human body produces similar substances ...Learn More
Those friendly neighbors on the northern U.S. border have a reputation for being fairly liberal minded. In fact, as of ...Learn More
As people continue to abandon cigarettes, vaping is becoming increasingly popular. And, as the range of vape oils, vape juices, ...Learn More
Ready to make your first CBD oil purchase but aren’t sure where to start? Well, you’ve come to the right ...Learn More
With so many CBD oil products and delivery formats available for purchase, knowing which one is right for you can ...Learn More
The hemp plant produces flowers just like its THC-toting cousin marijuana. Typically, this flower is processed and cannabidiol (CBD) is ...Learn More
CBD oil drops are one of the most popular ways to take cannabidiol (CBD). They are a cost-effective and convenient ...Learn More
If you’re new to the world of CBD oil, there’s a lot of new terminology to take in; one term ...Learn More
Is there nothing cannabidiol can’t do? The wonder compound—more commonly known as CBD—has been hailed as everything from a digestive ...Learn More
As an athlete, the less time you can spend doing online research, the more time you can devote to your ...Learn More
CBD oil microdosing is a concept that gets thrown around a lot these days, but what does it actually mean? ...Learn More
Because CBD oil has also been shown to reduce inflammation and swelling while promoting cell reparation, CBD topicals (e.g. balms, ...Learn More
When investigating cannabis products, it’s easy to become overwhelmed by all the varieties available. Cannabis oil, hemp seed oil, CBD ...Learn More
People are quickly becoming aware of the potential benefits of CBD oil, but this awareness has lead to one very ...Learn More
Today, it’s hard to go a day without hearing something about CBD oil, and for good reason. Cannabidiol (CBD) is ...Learn More
There are tens of millions of Americans who smoke cigarettes and millions of others who are suffering from smoking-related diseases ...Learn More
There are two main types of cannabidiol (CBD) extract utilized by vendors - purified, crystalline isolate, often labeled as ‘CBD ...Learn More
With frequent news reports about newly discovered uses for cannabidiol (CBD) in healthcare, a number of parents are investigating its ...Learn More
There is an increasing amount of coverage in the media about CBD oil and its potential uses and benefits. Everywhere ...Learn More
CBD oil interacts with the brain and central nervous system to produce a number of beneficial outcomes from reducing inflammation ...Learn More
The short answer: Yes...and no. If you’ve been following the national conversation about cannabis, you may have felt confused at ...Learn More
If you’re an athlete or fitness enthusiast who has heard about the many health benefits of cannabidiol (CBD), you may ...Learn More
In an age where a dizzying number of health supplements are readily available for the fitness enthusiast, separating the facts ...Learn More
In recent years, CBD oil has been used to treat certain symptoms of Alzheimer’s disease, including memory loss. This welcome ...Learn More
A growing number of cafes and eateries are advertising CBD-infused coffee and tea on their long list of caffeine offerings, ...Learn More
As cannabis legalization spreads, more and more people are considering cannabis products and wondering how to talk to their doctor ...Learn More
If you’re a close follower of skin and beauty product trends, you may have noticed a rise of CBD oil ...Learn More
As a breastfeeding mother, you know how carefully you need to monitor your consumption. Certain foods and drinks are off ...Learn More
There are several techniques available for extracting CBD oil from the cannabis plant. The two most common are ethanol extraction ...Learn More
CBD shatter is one of the purest forms of cannabidiol (CBD oil) that money can buy and it is completely ...Learn More
One of the first questions asked by people just learning about CBD oil is, “Can CBD oil get you high?” ...Learn More
CBD oil has been praised for its many potential health benefits and its use in the treatment of several chronic ...Learn More