The Complete Guide to Cannabinoids
CBD and THC have been in the spotlight, but which cannabinoid will be the next big thing?
Written by Cathy Rozyczko
Edited by Jason Brett on
September 27, 2021
The most famous cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is most widely known for its mind-altering, high-inducing properties, and CBD oil is rapidly gaining in popularity for its potential in relieving a host health complaints. But there are more cannabinoids than just THC and CBD.
In fact, it is believed that there are at least a few hundred different cannabinoids found in the cannabis plant and each one behaves a little differently in the human body. If you have been considering a full-spectrum CBD oil product in order to reap the benefits of the whole hemp plant via the entourage effect, then you need to understand these lesser-known cannabinoids. Or, if you’re on the lookout for the next big thing in the world of natural wellness and cannabis research, this should be your starting point.
Here is your complete guide to cannabinoids.
1) Cannabigerol (CBG)
CBG’s parent, CBGA, sits atop the cannabinoid family tree as it is the chemical precursor to THCA, CBDA, and CBCA, from which other major cannabinoids are offshoots. A non-psychoactive, CBG is believed to play a large part in the antibacterial nature of cannabis.
CBG interacts with the endocannabinoid system in a manner typical of phytocannabinoids, targeting receptors to reduce inflammation and pain. CBG has also shown potential to inhibit the growth of certain cancer cells, and to protect brain cells.
Go to the full guide on CBG
2) Cannabidiolic Acid (CBDA)
CBDA is found in the largest quantities in raw cannabis and hemp plants that with a high CBD content. CBDA is the raw, acid precursor to CBD. When heated, say by a flame or during the drying process, CBDA breaks down and becomes CBD through a process known as decarboxylation.
CBDA may not interact with the endocannabinoid system but instead affect other enzymes and receptors. One such interaction is between CBDa and the cyclooxygenase enzymes. These enzymes are responsible for the production of prostaglandins and reducing the experience of pain and inflammation.
CBDA may also be useful in treating mood disorders, like anxiety and post-traumatic stress disorder (PTSD). This unique cannabinoid has also shown promise as an effective anti-nausea agent, and in one study was even better than CBD at reducing nausea in the animal test subjects.
Go to the full guide on CBDA
3) Cannabidiol (CBD)
Cannabidiol has been the subject of much research of late. Found most abundantly in hemp, CBD can potentially support optimal health and homeostasis and it does so without any of the intoxicating effects of THC.
Affecting the CB1 and CB2 receptors indirectly, CBD has been shown to mediate the body’s response to pain and inflammation, protect the body from free radicals, and provide neuroprotective effects. Already used for the relief of chronic epilepsy, CBD has incredibly promising potential for its use in the treatment of a range of inflammatory, neurodegenerative, and mood-related conditions.
Go to the full guide on CBD
4) Cannabinol (CBN)
CBN is an interesting cannabinoid in that it is created through the degradation of THC and is generally not found in raw cannabis. The process in which CBN is produced occurs in the following order:
Effectively, CBN is created when cannabis is left for a prolonged period of time and is exposed to air, light, and heat. This degradation turns the psychoactive THC into CBN, which is a weaker psychoactive but also provides an additional sedative effect sometimes referred to as “couch lock,” a potential benefit for insomniacs.
CBN is an agonist of the CB2 receptors, meaning it enables their effects, and it also interacts with TRPV2 receptors which play a role in inflammation, metabolism, and cardiovascular functioning.
Go to the full guide on CBN
5) Cannabichromene (CBC)
Created from CBCA after exposure to heat or ultraviolet light, CBC is another of the non-psychoactive cannabinoids undergoing extensive research for a better understanding of its potential health benefits.
Like many other cannabinoids, CBC is known to relieve pain, reduce inflammation, promote bone growth and inhibit growth in tumor cells and fight bacteria. CBC appears to impact non-cannabinoid receptors and is most powerful when used as part of an entourage effect.
Go to the full guide on CBC
6) Tetrahydrocannabinolic Acid (THCA)
THCa is the primary cannabinoid found in raw cannabis and the substance from which THC is derived. When heated above a certain temperature THCA becomes Δ9-THC, the cannabinoid most well known for its presence in marijuana.
As an acidic cannabinoid, like CBDA and CBGA, THCA inhibits COX-1 and COX-2 to a significant extent, and is one of the main contributors to the anti-inflammatory effects found in cannabis. THCA has also been found to be an antispasmodic and has antiproliferative effects on tumor cells.
Go to the full guide on THCA
7) Tetrahydrocannabinol (THC)
The most common cannabinoid found in marijuana, THC is best known for its psychoactive properties. The “high” that is associated with marijuana comes from the reaction that THC has in the brain. THC does not just offer intoxication, it also has its own share of potential health benefits.
As an agonist of the CB1 and CB2 receptors, THC is an analgesic, reducing pain. Alongside this, research into THC at a cellular level has shown that it has neuroprotective and antioxidant properties.
Go to the full guide on THC
8) Tetrahydrocannabivarin (THCV)
Found only in particular strains of cannabis, THCV is structurally very similar to THC. However, while the THC molecule has a pentyl (5 carbon) group, THCV instead has a propyl (3 carbon) group. This difference modifies the effects of THCV, producing different effects on the body.
As an antagonist of the CB1 receptor, THCV has been found to suppress appetite and reduce panic attacks, making it a particularly beneficial cannabinoid in the treatment of eating disorders and mental health conditions. It’s also shown promise as an aid to diabetes sufferers.
Go to the full guide on THCV
This is a lot of information to take in but if you want to know more about cannabinoids, the endocannabinoid system, and how CBD oil could help you, check out the following articles:
Learn More About CBD
Athletes who participate in impact sports put a great deal of stress on their minds and bodies. Unfortunately, current methods ...Learn More
If you spend a lot of time with horses, then you know that they are incredibly intelligent and sensitive animals ...Learn More
With the passage of the Farm Bill in 2018, CBD became effectively legal in the United States. This ground-breaking legislation ...Learn More
All professional sports require a certain amount of athleticism and endurance, but there is perhaps no sport as physically and ...Learn More
Elevated cholesterol is something many people will have to contend with during the course of their life. So what is ...Learn More
If you’re a regular CBD oil shopper, you may have come across the US Hemp Authority certification seal on CBD ...Learn More
CBD oil is increasingly popular these days; there is a large market of CBD oil products, along with a growing ...Learn More
Whether your menstrual cycle brings abdominal heaviness, mild cramping, or several days of intense, throbbing pain, you're likely not looking ...Learn More
Anyone investigating the therapeutic potential of CBD has likely encountered more than a few sources claiming CBD products are legal ...Learn More
CBD and yoga can – and should – go hand-in-hand. These two vitality boosters are the perfect complement to one ...Learn More
The hemp plant harbors many potential benefits when cultivated and processed cleanly. While the euphoria cannabis is known for comes ...Learn More
CBD oil products are everywhere now, but ambiguity surrounding the use of CBD oil still abounds, especially in the world ...Learn More
Imagine this: you're curled up on your comfortable couch, surrounded by soft throw pillows, sipping a cup of hot chocolate ...Learn More
Though many people are still learning about cannabidiol (CBD) and its many natural benefits, the naturally occurring chemical compound has ...Learn More
A lot of people ask this question - is CBD oil legal in Florida? It appears that there has been ...Learn More
If you're just starting to learn about CBD and its potential benefits, you likely have many questions. There is so ...Learn More
Every plant on the planet has a purpose. Every piece of the ecosystem serves a purpose, and some lucky plants ...Learn More
For decades, people have been raving about the endless benefits of the hemp plant. Surprisingly though, some people may still ...Learn More
I’ve been poking around the interweb a bit for travelling with CBD tips and was a little surprised… I think ...Learn More
Delta 8 THC is the hot new cannabinoid on the wellness scene. As was the case with CBG a couple ...Learn More
The term ‘seed to sale’ is thrown around a lot in CBD marketing. CBD companies that claim to be seed ...Learn More
Delta 8 THC is one of the many cannabinoids found in the hemp plant. Like cannabidiol aka CBD oil, delta ...Learn More
We don’t have to tell you. You already know that CBD oil is one of the most important wellness discoveries ...Learn More
Hemp CBD has a confusing history of legalization that it shares with its intoxicating cousin, marijuana. Both the federal and ...Learn More
Like many people, it is likely that you have seen an increase in the popularity of CBD in the last ...Learn More
These days, it seems like everyone is talking about CBD oil and the benefits it can provide. Yet, if you ...Learn More
If you are interested in using CBD oil, but you live in Tennessee, you may have a lot of questions ...Learn More
Although the CBD industry continues to grow by leaps and bounds, many people interested in the cannabinoid's therapeutic potential are ...Learn More
If you live in Virginia, and you are interested in buying CBD oil, you may be wondering several things. For ...Learn More
CBD oil products have come to the forefront of discussions about non-traditional solutions to anxiety, pain, and other ailments that ...Learn More
CBD oil products have gained popularity in Michigan and across the nation because of the potential benefits they offer consumers ...Learn More
For fans of soccer (or football as most of the world calls it), there is likely a lot of speculation ...Learn More
A hemp flower is the most basic form of CBD and serves as the foundation for all other CBD products ...Learn More
The safety, legality, and absence of mind-altering properties make cannabidiol (CBD) a popular choice for those who want to reap ...Learn More
Between 2021 and 2027, the weight loss industry will benefit from a compound annual growth rate (CAGR) of 10.6%. As ...Learn More
If you live in Ohio and you are curious about using CBD, you may have a lot of questions. For ...Learn More
Cannabidiol (CBD) is one of more than 100 active compounds found in the cannabis plant. CBD oil manufacturers extract cannabidiol ...Learn More
If you were to ask a group of CBD enthusiasts for product recommendations, you'd soon discover that CBD users seem ...Learn More
In 2014, when the industry was still quite new, CBD generated nearly 50 million dollars in sales. That's pretty impressive ...Learn More
Industrial hemp was one of the very first domesticated crops, a plant harvested throughout history for its protein-rich seeds and ...Learn More
As you have likely heard by now, CBD has quickly become one of the biggest trends in the world of ...Learn More
Surprisingly enough, there are a lot of misconceptions floating around when it comes to cannabidiol. Cannabidiol, more commonly known as ...Learn More
CBD products are becoming increasingly popular in 2021, and CBD concentrates are no exception. If you've thought about trying CBD ...Learn More
Let's talk self care. Though you might think of self care as simply "pampering" yourself, it goes way deeper than ...Learn More
Texas Governor Abbott signed legislation clarifying which hemp products are legal and which are not. Looking for CBD in Texas? ...Learn More
CBD oil has many helpful-- not to mention, natural-- benefits physically and mentally. CBD has been heavily studied to relieve ...Learn More
If you are an avid runner, you are always looking for safe and healthy ways to improve your performance and ...Learn More
Can you use CBD if you are sober? Recovery from drug or alcohol addiction isn't just about abstinence. For many, ...Learn More
If there's anything we've learned from the last few years of incredible development, it's that the cannabis plant can take ...Learn More
By now, you are probably aware that there are a lot of CBD products on the market that can help ...Learn More
If you have never tried CBD oil and you live in Indiana, you probably have a lot of questions. You ...Learn More
CBD (short for cannabidiol) has become an alternative consideration for many parents around the world. Countless families swear by CBD ...Learn More
Birth control remains one of the greatest biomedical advances in the last century, giving women and couples the opportunity to ...Learn More
When shopping for CBD, it's essential to find the best product for your needs and your lifestyle. While CBD tinctures ...Learn More
For people who are considering CBD or have already started trying what is available, one of the most common questions ...Learn More
CBD oil is well known for its ability to regulate pain and inflammation, making it a valuable tool in the ...Learn More
Cannabinoid hyperemesis syndrome (CHS) is a true mystery. It can pop up out of nowhere for chronic cannabis users, and ...Learn More
When you first begin researching CBD oil, it can be hard to understand what you are reading. What exactly is ...Learn More
Death by overdose has become the largest killer of Americans under the age of 50, and with opioids responsible for ...Learn More
Because harvested and dried cannabis or hemp material only contains trace amounts of cannabigerol (CBG), it is often considered to ...Learn More
With cannabidiol (CBD) oil becoming more widely available, it is being sought out by an ever-growing number of people due ...Learn More
In 2018, the United States saw exponential growth in CBD oil product development and sales. Halfway through the year, the ...Learn More
The cannabis sativa plant contains hundreds of cannabinoids, each one presenting its own unique qualities and potential benefits. You may ...Learn More
Cannabinoids have taken over the natural health discussion, and with good reason. Research is continuously finding new ways in which ...Learn More
One of the lesser-known cannabinoids, cannabichromene (CBC) may be able to do some pretty incredible things. Recent scientific study has ...Learn More
Learning about the phytocannabinoids that exist in the cannabis plant family can feel a little bit like sifting through alphabet ...Learn More
Cannabidiol (CBD), is becoming widely used for its reported therapeutic benefits, which include pain reduction, nausea relief, and mood elevation ...Learn More
Tetrahydrocannabinol (THC) is probably the best-known cannabinoid found in the cannabis plant. THC is the psychoactive, intoxicating, and mind-altering compound ...Learn More
Of the many phytocannabinoids found in cannabis plants, tetrahydrocannabinol (THC) and cannabidiol (CBD) are likely the most well-known. That's why ...Learn More
The role of “Big Pharma” in healthcare is a contentious subject and one that’s working its way into discussions around ...Learn More
With more and more research coming out that shines a light on the reported health benefits of CBD and essential ...Learn More
Researchers are finding that CBD oil may be able to treat the symptoms of a whole host of diseases and ...Learn More
When you first decide to use CBD oil, it can be hard to know where to start. With so many ...Learn More
Health supplements are becoming increasingly commonplace as average Americans struggle to meet their recommended daily intake of vitamins and minerals ...Learn More
If you've spent any time reading about CBD oil and cannabis lately, it is likely you've seen terpenes mentioned more ...Learn More
If you’re interested in purchasing CBD oil but aren’t sure if it’s legal in your state, you’ve come to the ...Learn More
The CBD oil industry is one of the fastest-growing in North America and as such, it should come as no ...Learn More
Not long after the first cannabinoid was isolated from the cannabis plant, scientists discovered the human body produces similar substances ...Learn More
Those friendly neighbors on the northern U.S. border have a reputation for being fairly liberal minded. In fact, as of ...Learn More
As people continue to abandon cigarettes, vaping is becoming increasingly popular. And, as the range of vape oils, vape juices, ...Learn More
Ready to make your first CBD oil purchase but aren’t sure where to start? Well, you’ve come to the right ...Learn More
With so many CBD oil products and delivery formats available for purchase, knowing which one is right for you can ...Learn More
The hemp plant produces flowers just like its THC-toting cousin marijuana. Typically, this flower is processed and cannabidiol (CBD) is ...Learn More
CBD oil drops are one of the most popular ways to take cannabidiol (CBD). They are a cost-effective and convenient ...Learn More
If you’re new to the world of CBD oil, there’s a lot of new terminology to take in; one term ...Learn More
Is there nothing cannabidiol can’t do? The wonder compound—more commonly known as CBD—has been hailed as everything from a digestive ...Learn More
As an athlete, the less time you can spend doing online research, the more time you can devote to your ...Learn More
CBD oil microdosing is a concept that gets thrown around a lot these days, but what does it actually mean? ...Learn More
Because CBD oil has also been shown to reduce inflammation and swelling while promoting cell reparation, CBD topicals (e.g. balms, ...Learn More
When investigating cannabis products, it’s easy to become overwhelmed by all the varieties available. Cannabis oil, hemp seed oil, CBD ...Learn More
People are quickly becoming aware of the potential benefits of CBD oil, but this awareness has lead to one very ...Learn More
Today, it’s hard to go a day without hearing something about CBD oil, and for good reason. Cannabidiol (CBD) is ...Learn More
There are tens of millions of Americans who smoke cigarettes and millions of others who are suffering from smoking-related diseases ...Learn More
There are two main types of cannabidiol (CBD) extract utilized by vendors - purified, crystalline isolate, often labeled as ‘CBD ...Learn More
With frequent news reports about newly discovered uses for cannabidiol (CBD) in healthcare, a number of parents are investigating its ...Learn More
There is an increasing amount of coverage in the media about CBD oil and its potential uses and benefits. Everywhere ...Learn More
CBD oil interacts with the brain and central nervous system to produce a number of beneficial outcomes from reducing inflammation ...Learn More
The short answer: Yes...and no. If you’ve been following the national conversation about cannabis, you may have felt confused at ...Learn More
If you’re an athlete or fitness enthusiast who has heard about the many health benefits of cannabidiol (CBD), you may ...Learn More
Perfectly pent articles, regards for information .