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CBD Oil Dosage: General Tips to Assess How Much CBD to Take

By and large, the acceptance and use of cannabidiol as a therapeutic, healing substance is in its infancy. Medical professionals and scientists are only now beginning to develop dosing schedules for medical marijuana, medicinal hemp, and their extracts (including CBD).

Even with the current wave of states legalizing medical marijuana, many physicians are hesitant to prescribe cannabinoids like CBD. This is for two reasons:

1 – Doctors cannot prescribe (only recommend) cannabinoids, because there’s no recommended daily allowance (RDA) or universal dose for all people.

2 – Most medical schools never cover CBD/cannabidiol therapy in their pharmacology courses (the drug curriculum revolves primarily around substances that can be patented).

Because there is no recommended dose, the information presented on this page is intended to serve only as an informational guide – a starting point of reference – and should never be considered medical advice.

When it comes to cannabinoids, there is one universal truth to keep in mind:

Everyone Is Different

There are countless variables such as weight, diet, metabolism, genetics, environment, product consistency, and more that make a universally prescribed dosage an impossibility.

While we wish we could provide the public with a mathematical CBD dosage calculator, it isn’t quite that simple – very rough estimates are about as good as it gets.

With these facts in mind, most people who are new to cannabidiol begin their journey by starting with the minimal suggested CBD dosage on any product, then gradually increasing the dose until they achieve the desired results.

We at CBD Oil Review (COR) have created an official COR Serving Standard through an extensive analysis of hundreds of CBD products.

The (COR) Serving Standard is 25mg of CBD, taken twice daily.

Additionally, our analysis suggests  increasing the amount of CBD you take every 3-4 weeks by 25mg until you attain symptom relief (inversely, decrease by 25mg if symptoms worsen).

Additionally, you might find it useful to record your daily experiences in a notebook so you can accurately narrow in on what works and feels best for you. With that understanding in place, it is now time to learn more about CBD oil and how to find the right CBD oil dosage for you.

How Much CBD Oil Should I Take?

Mayo Clinic suggests CBD dosages based on scientific research, publications, traditional use, and expert opinion. Cannabinoid dosages and duration of treatment depend mainly on the illness (and countless other factors).

The Mayo Clinic provides specific dosage recommendations for various illnesses, including:

  • Loss of Appetite in Cancer Patients: 2.5mg of THC (orally), with or without 1mg of CBD for six weeks. [S
  • Pain Relief: 100-150mg of CBD, or 25mg when combined with THC.[S, S, S]
  • Epilepsy: A daily dose of 20 – 25mg of CBD per Kg bodyweight. [S, S]
  • Movement Problems Due to Huntington’s Disease: 10mg of CBD per kg of body weight daily for six weeks (orally). [S]
  • Sleep Disorders: 40mg-160mg of CBD (orally). [S]
  • Multiple Sclerosis (MS) symptoms: Cannabis plant extracts containing 2.5-120 milligrams of a THC/CBD combination daily for 2-15 weeks. Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24-hour period. [S]
  • Schizophrenia: 40-1,280mg oral CBD daily. [S]

Learn the Types of CBD Products

CBD hemp oil comes in seemingly endless forms, each with a different concentration of CBD and other phytocannabinoids. Determining how to use CBD oil first starts with choosing your route of administration – in other words, choosing the best way to take CBD oil for your needs and lifestyle.  

These include…

Ingestibles:

  • Liquid hemp oil, like CBD tinctures or CBD drops
  • CBD concentrated into a thick paste (often referred to as Rick Simpson Oil, or RSO)
  • Encapsulated CBD oil
  • Phytocannabinoid-rich sprays/spritzers (generally designed for application beneath the tongue)
  • Bottled water containing nano-sized CBD particles
  • CBD-infused chewing gum
  • On-the-go dissolvable powders containing CBD (oftentimes blended with other adaptogenic herbs)
  • Cooking oils (such as coconut oil or olive oil) with added cannabinoids
  • CBD-infused edibles (i.e., gummies, brownies, cookies, etc.; generally for individuals who are sensitive to smoking/vaping)

Smokables:

  • Crystalline isolates
  • Wax (similar to THC-containing marijuana concentrates called “shatter”)
  • CBD-rich eLiquids and/or vape cartridges (akin to an e-cigarette)

Topicals:

  • Transdermal patches with CBD (similar to a nicotine patch)
  • Cannabidiol-infused salves,balms, lotions, shampoos, or soaps (for topical use)
  • Bath bombs infused with CBD

Decide How to Use CBD Oil

While many options like chewing gum need no instructions, we have compiled these tips on how to take CBD oil:

Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.

CBD E-Liquid/Vape Cartridges: Vaping is excellent for people looking for an immediate response, as inhalation is the fastest way to deliver CBDs to your brain and body. To use vape simply exhale gently the air from your lungs then inhale through the mouthpiece slowly for 3 seconds. Then fill your lungs the rest of the way with additional breath and hold for a few seconds, exhaling when ready. There are pre-filled, cost-effective vape pens and cartridges available as well as more expensive vaporizers that you can refill with CBD-infused e-liquid.

CBD Edibles: With edibles, the only required steps are open, eat, and enjoy! This method of consumption will result in more drawn-out effects that also take longer to kick in than some of the other options. Edibles are great for those seeking sustained effects, or for those who want to be subtle about their usage of CBDs.

CBD Isolates/Concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this delivery method. Simply sprinkle some into a vaporizer or water pipe, ignite, inhale, and enjoy! We find that this option is useful for individuals looking to elevate their regular consumption of CBD-rich cannabis flowers or other smokable herbs.

For quick reference, refer to this chart of ingestion methods for the pros and cons of each delivery method so can decide for yourself the best way to take CBD oil:

Delivery Method Pros Cons Time of Onset Duration of Effects Recommended if you…
Ingestibles (E.g. edibles; capsules; oil drops; drink powders) Convenient; Dosage control; Discreet; Familiar; Doesn't harm the lungs Slow to take effect 30-60 minutes Edibles/Capsules:4-6 hours; Tinctures/Drops: 2-4 hours Consider discretion a top priority and/or want more control over dosage
Smokables (E.g. Vapes; flower) Fast acting; Easy to use; Social; Familiar Non-discreet; Smoking/Vaping are illegal in many public settings; Can feel harsh on the lungs Instant 45 minutes-1 hour Are trying to quit cigarettes or need fast-acting relief
Topicals (E.g. Lotions; balms; gels) Can be applied directly to affected area; Bypasses liver metabolism; Long-lasting; Can be worked into daily hygiene routine Slow to take effect Varies widely due to factors like hair growth and amount of fatty tissue Typically 5+ hours Experiencing local pain of the skin or joints or into body care in general.
Transdermal Patches Longest lasting effects;Bypasses liver metabolism;Steady release of CBD into the bloodstream May take hours to feel effects Varies depending on amount of fatty tissue and hair on the skin 1-2 days Have chronic pain or will go a long period of time where the other delivery methods aren't available

Choose a CBD Brand with a Dosage You Can Trust

Figuring out how much CBD oil to take can feel like trying to navigate through a complicated maze. The sheer volume of CBD brands on the market can create confusion for consumers, and when you take a closer look, it’s not difficult to understand why. Not only do vendors use different source materials (CBD-rich cannabis vs. industrial hemp, different strains, etc.), but they also implement different extraction techniques .

Adding to the confusion, many vendors recommend excessive doses, while others suggest amounts that are a fraction of what experts would consider effective.

As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.

While perhaps not as ideal as a CBD dosage chart, we at CBD Oil Review (COR) have created an official COR Serving Standard through an extensive analysis of hundreds of products.

The (COR) Serving Standard is 25mg of CBD, taken twice daily.

Additionally, our analysis suggests  increasing the amount of CBD you take every 3-4 weeks by 25mg until you attain symptom relief (inversely, decrease by 25mg if symptoms worsen).

Consider Why Your Health Would Benefit from CBD

Cannabinoids such as CBD have a dizzying array of functions in the human body, influencing  everything from inflammation to anxiety and depression. You don’t necessarily need to have a serious illness to benefit from CBD; even healthy individuals can experience a remarkable increase in their quality of life with its use.

The following is a chart of illnesses/conditions that whose symptoms may be relieved by CBD:

Keep in mind that this CBD benefits list is in no way complete; we are only beginning to discover how cannabinoids can help.

Know You Cannot Overdose on CBD

There is no established lethal dose of CBD, and chronic use/high doses of up to 1500 mg per day (30x  MORE than the COR Serving Standard!) have been repeatedly shown to be well tolerated by humans.

As with any natural product, it is important to speak with your physician prior to beginning use. There are some slight risks associated with using CBD in high doses or for extended periods of time, including:

  • Mild Low Blood Pressure
  • Dry Mouth
  • Lightheadedness
  • Sedation
  • Reduced activity of T and B Cells
  • Decreased Fertilization Capacity
  • Reduced p-Glycoprotein activity
  • Reduced activity of Cytochrome P450 (CYP450) Enzyme

Keep in mind that these side effects illustrate worst-case scenarios with CBD, and are not necessarily typical.

There is one major exception to the “generally harmless” attitude about CBD and that is the negative effect cannabinoids can have on the functioning of the liver’s CYP450 enzyme. Approximately 60% of all pharmaceutical drugs are degraded by this enzyme, and CBD can slow the metabolization of these drugs:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV-antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

Before you start taking CBD, please read about drug interactions.

It is important to note that even something as benign as grapefruit juice can cause the same CYP450 enzyme inhibitory action as CBD.

The most important things to do before taking CBD (or any other herbal product) are research any possible drug interactions and talk with your physician to address any additional questions regarding CBD drug interactions or overdose concerns. You and your doctor together will always know best!  

Understand How Your Genetics Impact CBD Dosing

As if you didn’t have enough factors to consider when deciding your ideal CBD oil dosage, now you have to think about how your own genetics can impact this amount.  

Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system, which is an important variable when figuring out how to use CBD oil.

How lifestyle choices impact the effect of CBD

Various substances can profoundly affect CB1 receptors. Certain lifestyle choices can impact how your body metabolizes CBD.

We are only beginning to understand which factors influence CBD metabolism, and as such it’s a good idea to take anything related to this emerging science with a grain of salt. As with any natural substance, consult with your physician about any questions and/or concerns you may have regarding CBD and how to use CBD oil.

Rest Easy Knowing CBD Oil Is Not Physically Addictive

People often ask us, “Can I get addicted to CBD oil?” This is a tricky question, and the answer ultimately depends on your school of thought.

Based strictly on chemistry, the answer is no. Cannabidiol is not physically addictive in the same way substances like heroin, cocaine, alcohol, opiates, benzodiazepines, and related substances can be. Further, CBD cannot produce any physical withdrawal symptoms in and of itself upon cessation of use.

(Interestingly, CBD is currently undergoing study for its ability to minimize withdrawal from drugs with severe cessation symptoms, like opiates.)

However, human beings can get addicted to just about anything that isn’t chemically addicting: exercise, music, sex, and food are great examples.

Those who take CBD daily to relieve symptoms of chronic illness and other severe conditions may find that their unpleasant sensations return shortly after they miss a dose. This is no different than one’s headache returning once the effects of ibuprofen wear off.

However, because CBD can alter the levels of essential liver enzymes, it is crucial to do your research, talk to your physician, and figure out the best way to take CBD oil for your specific situation. Information and education will be your allies in your quest for healing.

Get the Most Bang for Your Buck

If you’ve been using CBD products for some time without verifying the potency through their vendors, it’s highly probable you’ve been using a minimally effective formulation that hasn’t been delivering as much CBD as you thought (or as much as you’ve paid for!).

This is why CBD Oil Review exists, why we’ve created our five-badge rating system, and why we’ve enlisted independent reviewers to verify that CBD companies are being ethical.

Becoming a CBD Oil Review member not only supports our mission, but members also get new deals on five-star brands only, delivered directly to their inbox. If you are looking for which brands to trust or which products to purchase, take a look at our buyers guides here:

  1. Top 10 Best Products to Buy
  2. Best CBD Products for Pain
  3. Best CBD Vape Cartridge

Consider a Cannabis Doctor to Answer Your Difficult Questions

Most doctors don’t specialize medicinal cannabis and CBD oil. This means they may not be able to help you as thoroughly as you had hoped and they may be unable to offer guidance when it comes to helping you decide how much CBD oil to take. It is also worth noting that many patients feel uncomfortable talking to their doctor about cannabis and CBD.

If you have detailed questions about how much CBD oil to take, how to take CBD oil, drug interactions, or just want to know what to do next, consult with a cannabis doctor today!

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281 responses to “CBD Oil Dosage: General Tips to Assess How Much CBD to Take”

  1. Avatar Mike says:

    This advice given on how much to take is so vague and unrealistic it’s nothing short of guessing work. It’s ridiculous and totally conflicting with other recommendations from other sites/places.
    It makes me wonder if cbd oil even does anything at all.I think it’s all just a bunch of money grabbing nonsense.

  2. Avatar Rhiannon says:

    How many drops do I take for a bottle that’s 240 mg bottle for anxiety?

  3. Avatar Amy Anderson says:

    Very interesting and informative article pal! I found it interesting that CBD oil can help you to sleep better by relaxing your body and mind. But Over dosage can make you addictive and it will also effect health in way or other.

  4. Avatar Melanie says:

    Was this just 300mg cbd oil no thc in it?

  5. Avatar ivan says:

    Thanks for sharing such great information, it is really helpful. Keep up the work.
    I found it interesting as the article explains that CBD oil can help you to sleep better by relaxing your body and mind. My sister has difficulty relaxing at night so she doesn’t sleep well. I will suggest that she try CBD oil to help her relax. There’s this other related article
    https://www.calicannadispensary.com/the-backbone-of-cbd-oil/
    Please Read and thank me for sharing

  6. Avatar Beth says:

    Diamond Cbd. All there products have no THC.

  7. Avatar Chris says:

    Hi Karen, definetly use CBD Oil. It will help you alot. give a space of 2 hours between medication.

  8. Avatar Vuthy says:

    CBD has interesting benefits for sure.

    This dosage guide is nothing short of awesome.

    I read another dosage guide and the editor had similar views on how to take the dosage. Also it was interesting to know that you can’t overdose on CBD.

  9. Avatar Ron Knox says:

    I’m dealing with the same thing. Thanks for explaining the great results you’ve had. I’m definitely going to give it a try. ?

  10. Avatar Ashley says:

    I thought that it was interesting when you said that one thing to consider when you have sleeping disorders is to use CBD oil. I have been experiencing sleeping disorders and haven’t been sure how to resolve this issue. I will be sure to consider using CBD oil to help resolve this difficulty.

  11. Avatar bj says:

    You can take gummies that have 25mg of cbd. I take 10mg cbd tincture and 10mgs is one dropper full.

  12. Avatar Cannatonic says:

    This will depend on how many mg are in the bottle.
    Low mg such as 250mg/30ml bottle will require 3 full ml or 10% of the bottle. We recommend using a higher dosage such as 1000mg/30ml which will supply 33.3mg per full dropper. Remember to place under the tongue for better Bio-availability.

  13. Avatar Jack Ken says:

    I’ve been using a Knockout CBD tinctures and their CBD Hemp flower, for arthritis pain, insomnia and anxiety. I buy it from online and I can honestly say it really helps. I’ve tried going without it and I can tell.

  14. Avatar Amy says:

    Any recommendations for energy? I have narcolepsy.
    Thanks

  15. Avatar Ryan Neil says:

    Anywhere from 5mg to 25mg spread throughout the day (2 or 3 doses). Keep in mind, to have very serious negative effects from taking too much CBD oil is more than 20,000 mg.

  16. Avatar Ryan Neil says:

    Hi Tiffany. I too suffer from ADHD and have found THC an also CBD to be very calming yet focus driven. Perpetually better than taking Adderall or any synthetic stimulant that “claims” to relieve the symptoms of ADHD, but in truth makes the problem much worse due to a dangerous chemical restructuring many pharma pills create. For your daughter about 10ml or 20ml would be a great starting point. CBD will help, that I know for certain. Best wishes to CBD naturally helping your daughter!

  17. Avatar Ryan Neil says:

    Anywhere from 50ml to 200ml. Conduct your own scientific experiment by starting at a low dose, say 25ml and see how you react to that amount of CBD.Ether up the dose or lower the dose. I recommend CBD vape cartridge or tinctures. Hope this helps and you have a speedy recovery!

  18. Avatar Ryan Neil says:

    The tincture dropper usually has a mg display on the glass dropper that sucks up the oil. For example, I’ve used many that go from 5ml 10ml 25ml 50ml etc. It’s best to suck up a small amount first like 10ml and see how you react to that. Then you will have a basis of the effects CBD produces when using the tincture method.

  19. Avatar Rober White says:

    Good read. We at KanaRelief.com believe in the impact of CBD in helping people change their lives for the better and allowing them to lead healthier and more fulfilling lives.

    KanaRelief is efficiently run and always friendly. Tell us what you need and we’ll help you get that much closer to beating cancer or other ailments you wish to defeat

  20. Avatar Cannabria CBD says:

    Really helpful article. I liked it has to work for you to be effective. Thanks for sharing.

  21. Avatar ANNA GRIFFIN says:

    My favorite is CBD Cure’s Oral Tincture (500 mg) in Orange. All their products are THC free and amazing!

  22. Avatar Sandalah says:

    My mother fought a rare cancer, Angiosarcoma. She was helped tremendously from taking the Rick Simpson oil. But it was only afterwards that we realized she needed a much higher dosage for her cancer. Her medicinal grade dosage helped eradicate all inflammation and this was very visible, she slept better and helped with the side effects of chemo. Applied topically, it removed and arrested the spread of the cancer. But being a soft tissue cancer, it was impossible to completely cure on the dosage she was taking. I wish I knew that before she died.

  23. Avatar Preci says:

    I found mine a Natures Health Store THC free

  24. Avatar David Adams says:

    How many drops for knee pain

  25. Avatar L says:

    Why would you want to put something like this in your body created by big pharma. Go get a natural real CBD oil. I’m speechless ?

  26. Avatar Sophia says:

    Thanks for sharing the information about Cbd products and how its growing. Cbd products are gaining popularity among people and they are gaining lots of benefits from these products.

  27. Avatar Jackie Dorner says:

    What were the results at 200mg twice a day? I saw studies @ 600mg a day but who sells pills in this strong?

  28. Avatar ella says:

    but it’s not only CBD in this drug. one of the side effects is suicidal thoughts. please be careful.

  29. Avatar Liz says:

    Did you ever find out cuz I’m also in same boat

  30. I have nerve pain and rods in my back which is painful how many drops should I take.

  31. Avatar Jason says:

    Ur looking for THC free products. They are very common. I tested positive on a drug test

  32. Avatar Judith says:

    If Im supposed to take 25mg of CBD Oil, approximately how many drops is that?

  33. Avatar Larry Weaver says:

    I didn’t realize that you could have cooking oils with added CBD as a way to meet your needs. My wife has a medical condition that will require her to take CBD, and we are trying to find natural ways she can take it. We should look into different types of ingestibles, such as enhanced cooking oils, that my wife could use.

  34. Avatar Karen Sherry says:

    I also suffer from seizure disorder and am taking keppra, I also take clonazepam because of anxiety and panic attacks…I have tried almost every thing out there…please if you have an idea of how to use THIS please let me know ?

  35. Avatar Dave Anderson says:

    That is interesting that there are such things are CBD infused chewing gum. Maybe it would be good to get some gum for my father who is going through cancer treatment. Then he would be able to have a little less pain while going through the treatment.

  36. Avatar Rose says:

    I have digenerative disc disease/4 bulgin discs was taking 9—10mg hydrocodones a day… i started with 3 drops of 300mg and within 5 mins started feeling better than i have theses last 6 years or so… not only that, the inflamation has decrease substantially, i wake up with energy and have begun to work out again… if im making it seem like a miracle drug… its because it is… so the first week i took 3 drops twice a day… now 3 weeks in… im taking about 5 drops 3 times a day and zero pain pills… for the first time in years i have taken control of my life agin… not depending on doctor scripts/bills etc….

  37. Avatar JOAN says:

    How much CBD oil is best for a broken fibula?

  38. Avatar Buddy says:

    CBD is not an illegal substance. Also, the compound they test for if you have used Cannabis is THC.

  39. Avatar Ron says:

    We just purchased our first 1000mg tincture for my wife’s anxiety

  40. Avatar Diane says:

    Thank you for that Nate, been looking for this answer and you provided

  41. Avatar Tiffany says:

    My 12 year old daughter has severe adhd. I have been considering trying cbd oil for her but I have no clue what mg to give her. Can anyone help me with that?

  42. Avatar Lu Russell says:

    It is also best not to eat or drink anything after you take your dose it will give you a better intake for your body. I also hold mine under my tongue more than 60 seconds the long the better to get in your system Start off with 2 drops x twice a day and increase after about 5 days to more for your body weight and what you may be taken it for. Good Luck!

  43. Avatar marlin says:

    I am taking 3 drops under tongue 2x a day for neuropathy.. it has helped the shooting pain. still trying to figure dosage and brand.

  44. Avatar Mantis says:

    The author didn’t state that at all. This is actually an issue with the website. Look closely at the tables- the middle column is shifted upwards the father down you go, at least on my phone browser. Obviously edibles are slower to take effect than smoked/vaped. Web admin, please look into this, so people don’t get confused. Great article!

  45. Avatar Tracy says:

    Make sure you check the brands third party testing. A lot of companies claim THC free when in fact there are traces of THC in their products. Also if a company does not provide third party lab results up front or at all, I would never buy from them.

  46. Avatar Stephanie says:

    I havnt heard of that med but, our doctor gave us epidiolex which the state insurance paid for but we are only on 6.5mg x2daily. It’s to help control his seizures along with his other medication he is taking..

  47. Avatar Stephanie says:

    As of recent…YES THERE IS A FDA APPROVED CBD OIL a doctor can prescribe called Epidiolex. We got it from our neurologist and CVS pharmacy filled it and insurance covered it.

  48. Avatar Pare says:

    cbd formulations and methods of treating diseases with cbd can be patented.

  49. Avatar Lisa says:

    I’d recommend using cbd oil with thcm as the thc will stimulate his digestive system….

  50. That is interesting that CBD oil can help people who have a loss of appetite from cancer. Maybe it would be good to find a CBD dispensary for my brother. Then he would be able to help his appetite be better so he gets nutrition.

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