CBD Oil Review > 10 CBD Facts You Need To Know

10 CBD Facts You Need To Know

CBD…is it legal? Is it legitimate? Is it safe to consume? Find the answers to these questions and more.

Written by Cathy Rozyczko — Edited by Jason Brett on October 7, 2021

1. CBD is a Main Component of Cannabis

Cannabidiol (CBD) is a primary component of cannabis. It is one of more than 85 compounds unique to the plant and grouped under the umbrella term cannabinoids. CBD and THC are the most prominent cannabinoids found in cannabis, and as such have undergone the heaviest scientific study.

2. CBD Oil Won’t Get You High

CBD does not cause the feeling of being ‘high’ that is often associated with cannabis. The high is caused by THC. THC binds tightly to the CB1 and CB2 nerve receptors in the brain and throughout the body. CBD does not bind to these receptors and instead causes its therapeutic actions through more indirect means.

Because CBD will not make you feel intoxicated, it is a great option for parents, workers, and anyone else who does not want to compromise their mental clarity.

Many health conditions, both severe and not, are treated with pharmaceutical drugs. Unfortunately, many of these drugs have unpleasant or dangerous side effects. In some instances, CBD may offer non-toxic, virtually side-effect free, natural benefits for individuals who want to avoid or reduce the number of pharmaceuticals they are taking.

3. CBD Oil from Hemp is Legal

CBD products come either from medical cannabis or industrial hemp plants. While still illegal under federal law, cannabis is legal in several states. And because it has a low THC content (>.3%), industrial hemp does not fall under these same regulations. This means that consumers are free to choose CBD as a natural supplement without worrying about any legal repercussions.

4. The Human Body Produces Cannabinoids, and CBD Oil Helps

Phytocannabinoids are cannabinoids derived from plants. Endocannabinoids are cannabinoids produced naturally in the human body.

One example of an endocannabinoid is anandamide, or ‘the bliss molecule.’ This molecule activates the CB1 receptor.

Benefits of activating the CB1 receptor include:

Relieving depression [S]
Increasing myelin formation [S]
Lowering intestinal inflammation [S]
Decreasing intestinal permeability (Leaky Gut Syndrome) [S]
Lowering blood pressure [S]
Lowering anxiety [S]
Increasing PPARy expression [S]
Reducing GPR55 signaling [S]
Lowering prolactin [S]

An enzyme in the body known as FAAH is responsible for breaking down anandamide. CBD is an inhibitor of FAAH, meaning more anandamide to be available to the CB1 receptors.

Anandamide has been shown to stop the proliferation of breast cancer cells, promote anti-anxiety and antidepressant effects, and increases neurogenesis. Anandamide plays a role in memory and forgetting, creating a potential natural value for individuals with post traumatic stress disorder (PTSD).

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5. CBD Oil Effects Several Neurotransmitter Receptors

CBD is an allosteric modulator at several receptor sites in our bodies.

Allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters.

CBD is a positive allosteric modulator of the mu and delta opioid receptors. This means it enhances the ability of these receptors to receive endogenous enkephalins which can increase quality of life and naturally reduce pain.

Inversely, CBD is a negative allosteric modulator of the CB1 receptor, reducing its ability to bind with THC; this explains why high-CBD cultivars of cannabis mitigate many of the unwanted side effects associated with THC. [S], [S]

At high doses, CBD activates the 5-ht1A receptor. The 5-ht1A receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA (the raw form of CBD) shows an even higher affinity for the 5-ht1A receptor than CBD. [S]

CBD also antagonizes GPR55 receptors. GPR55 receptors are widely distributed in the brain (especially the cerebellum) and help to control bone density and blood pressure.

When activated, GPR55 promotes cancer cell proliferation. This antagonizing action may help explain the natural value of supplementing with CBD in individuals with cancer, osteoporosis, and high blood pressure. [S]

CBD activates TRPV1 receptors. TRPV1 is involved in regulating pain, body temperature, and inflammation. Other substances targeting TRPV1 receptors include anandamide, AM404 (a metabolite of acetaminophen), capsaicin, and various cannabinoids such as CBN, CBG, CBC, THCV, and CBDV.

Lastly, CBD activates PPAR-gamma receptors. PPAR-gamma receptors are located on the cell’s nuclei and play a role in lipid uptake, insulin sensitivity, dopamine release and the degradation of beta-amyloid plaque. This is why CBD has been found to have natural value for individuals with diabetes, schizophrenia, and Alzheimer’s disease. [S]

6. CBD Oil May Help with Clinical Endocannabinoid Deficiency (CECD)

Clinical Endocannabinoid Deficiency is a condition where an individual has a lower amount of endogenous cannabinoids than is considered necessary to promote health and well-being.

Scientists now believe CECD may play a role in the following conditions:

Fibromyalgia
Irritable Bowel Syndrome (IBS)
Migraines
Multiple Sclerosis (MS)
Post-Traumatic Stress Disorder (PTSD)
Neuropathy
Huntington’s
Parkinson’s
Motion Sickness
Autism

Many of these conditions are treated with a range of medications that carry some heavy side effects. As the research develops, if CECD is found to be the culprit behind these conditions, CBD would help increase endocannabinoids in the body without many of the risks associated with pharmaceuticals.

7. CBD Oil Has Numerous Natural Benefits

Cannabidiol is one of 85+ cannabinoids found in the cannabis plant, and much of the ongoing research has found it to be a promising potential therapy for many illnesses that medical professionals have previously thought to be untreatable, including:

Pain (neuropathic, chronic, cancer-related, etc.)
Epilepsy
Multiple Sclerosis (MS)
Amyotrophic Lateral Sclerosis (ALS)
Parkinson’s
Inflammation
Acne
Dyskinesia
Psoriasis
Broken Bones
Mad Cow Disease
Depression
Viral Infections
Diabetes
Rheumatoid Arthritis
Nausea
Anxiety
ADHD
Schizophrenia
Substance Abuse/Withdrawal
Heart Disease
Irritable Bowel Syndrome (IBS)

8. CBD Is But One Part of the Entourage Effect

The entourage effect describes the phenomenon where the 400+ compounds in cannabis work in concert to have a synergistic effect on the body. In other words, it is the sum of its parts that make cannabis so effective.

For example, 100mg of isolated CBD may be substantially less effective at alleviating symptoms than 100mg of a whole-plant, cannabis extract.

Vitamin C may be a good analogy. Many vitamin C supplements are presented in the form of ascorbic acid. Ascorbic acid is just one of the many compounds that comprise the whole vitamin C. In order to be most effective, vitamin C must also exist alongside rutin, Factor K, Factor J, Factor P, Tyrosinase, and Ascorbigen. In fact, in all of his years of research, the discoverer of Vitamin C and Nobel prize laureate Dr. Albert Szent-Georgi was never able to cure scurvy with isolated ascorbic acid. In contrast, eating an orange provides whole vitamin C with all the necessary cofactors for optimum absorption.

It is this very concept that lies at the center of the CBD oil from hemp vs. CBD oil from cannabis debate.

While it may be cheaper and more cost-effective to extract CBD from industrial hemp, users may ultimately experience fewer benefits due to the absence of clinically significant levels of terpenes and other compounds which occur in abundance in high-CBD cannabis.

Agricultural hemp is much closer to the kind of cannabis that one would find growing naturally, whereas high-CBD cannabis is hybridized and altered by growers to produce the highest levels of the desired compounds.

Unfortunately, there are no hard facts about the validity of the entourage effect. It is up to each individual to research, consult with medical professionals, and decide for themselves the best path forward.

9. CBD and THC Have Different Benefits for Pain

Research suggests CBD may be better for inflammation and neuropathic pain, while THC may excel with spasticity and cramp-related pain.

High doses of THC can exacerbate current pain symptoms making micro-dosing with THC a more reasonable pain management strategy.

Many people experience difficulty managing the side effects of THC, and because CBD can mitigate these side effects, some experts to suggest a combination of THC and CBD as a more manageable approach to treating pain.

THC is illegal and carries considerable immediate and long-term cognitive side effects. These include impaired thinking and reasoning, a reduced ability to plan and organize, altered decision-making, and reduced control over impulses.

In addition, chronic use of THC correlates with significant abnormalities in the heart and brain. CBD lacks many of these harmful effects.

Given the increasing popularity of medical marijuana, breeders are currently creating strains with higher CBD to THC ratios to minimize these psychoactive side effects.

Overall, the lower health risks of CBD, combined with its efficacy, make it a better candidate for natural supplementation than THC.

10. CBD Oil Helps Children with Seizures and Epilepsy

Perhaps one of the most exciting applications of CBD oil is its potential impact for adults and children with epilepsy.

Individuals who were experiencing dozens of seizures daily have found that CBD can dramatically decrease these numbers.

Considering the shocking increase in children receiving prescriptions for various ailments, CBD oil may provide a non-toxic more natural alternative to pharmaceutical treatments, preventing children from experiencing long term damage or side effects.

+ 33 sources

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22 responses to “10 CBD Facts You Need To Know”

zoritoler imol says:

October 24, 2022 at 5:01 am

I do like the manner in which you have presented this specific problem and it does indeed offer us a lot of fodder for consideration. However, because of what I have seen, I only hope as the actual reviews stack on that people continue to be on point and in no way embark upon a soap box associated with the news of the day. Still, thank you for this exceptional piece and though I do not really go along with it in totality, I respect your point of view.
Alaska CBD says:

August 21, 2020 at 9:12 pm

What a fun read – Iâ€™ll be sharing with my husband. This is appreciated!
Alice Carroll says:

August 19, 2020 at 10:56 pm

It’s good to know that CBD products can help in relieving pain. Chocolate tends to be my comfort food nowadays whenever I need an extra boost in productivity. Maybe getting CBD-infused chocolate bars can also be the kind of food I should eat during situations when I have to relax a bit.
Austin Saunders says:

February 18, 2020 at 9:09 am

It’s great that CBD can help with inflamation. My sister has been telling me about how her joints have been swollen recently. I’ll share this informaiton with her so that she can look into her options for CBD products that can help her with this.
CBD soothe says:

December 17, 2019 at 12:21 am

Interesting discussion. I think that you should write more on this topic, it might not be a taboo subject but generally people are not enough to speak on such topics. Cheers
Anna Dawn says:

December 9, 2019 at 11:32 pm

Very nice article! CBD is an amazing element. It improves immunity and repairs skin or body damage that’s why it has many benefits to athletes.CBD oil for skin care or other products are not addictive these are way healthy and beneficial. A drop a day can change your life.
Con says:

December 5, 2019 at 6:37 am

When it comes to CBD oils does the form it is taken in have any impact on the effectiveness of the CBD? I ask this as the drops did not work for me.
Randy Chorvack says:

October 7, 2019 at 7:12 am

It’s really interesting that CBD oil won’t get you high when you take it. That’s really good news because I’m hoping to take some for my pain but I don’t want to be addicted. I’ll make sure that I take the right dosages anyway.
Luke Smith says:

September 13, 2019 at 11:05 am

It’s great to know that flavored CBD oils give natural benefits to the user and don’t have side effects. My father has been diagnosed with a heart condition, and he wanted to find other treatments aside from the regular hospital procedures. I’ll keep this in mind and talk to experts who can recommend the right CBD oil that he can use.
Proceed to this site. says:

May 28, 2019 at 2:10 pm

Real clean internet site, thank you for this post.
Denisr says:

May 24, 2019 at 5:33 pm

Is CBD oil ototoxic?
LouG says:

May 17, 2019 at 10:43 am

I would be really interested in reading or studying his info source, as I’m looking for reliable info on that subject. Everything I’ve found so far has come from people who stand to profit by selling to me. Something more objective would be great.
Sam Taylor says:

April 30, 2019 at 5:37 pm

How to sensibly buy LEGAL CBD oil? Because I got a letter saying customs have confiscated my package two times already and I’m pissed.
Bree Ward says:

March 20, 2019 at 9:53 pm

I like it when you said that cannabis has many potential health benefits to fight illnesses like acne, inflammation, heart disease, etc. My father has a heart condition, and he plans to try medical cannabis treatment. he is now looking for medical clinics who can give him recommendations.
Kathy campbell says:

March 19, 2019 at 4:47 am

Can I still take cbd oil if I am taking amitripiline I only take like25mg of the depression medicine
Lingard Ellis says:

March 7, 2019 at 7:31 pm

My Mother was diagnosed with ALS in 2018 following a year of doctor visits and tests aimed at finding a cure for her slurred speech, difficulty swallowing, and weakening limbs. By the time she was diagnosed, she had developed pneumonia and was put on a respirator. A family friend visits us and told us about Solution Health Herbal Clinic and their successful ALS TREATMENT, i am happy to report the treatment effectively treated and reversed her Amyotrophic Lateral Sclerosis (ALS), most of the symptoms stopped, she is able to walk and able to ride her treadmill again, she is pretty active now and can do everything again.
Misty kane says:

March 7, 2019 at 10:26 am

I am a survivor of Triple Negative Breast Cancer (a rare type). I would like to know what the best method, regiment, and dosing would be for me to keep my cancer at bay. When diagnosed 4 yrs ago I took RSO tincture for 3months which shrank the tumor to 1/4 its original size. I believe, without doubt, that cannabinoids are the key to keeping me alive. My aunt, now diagnosed a 4th time, tells me I definitely need to stay on top of it in order to control it.
Thank You for all this wonderful website providing vital information to those who quite literally live by it.
Ellen Keir says:

March 3, 2019 at 5:26 am

Can CBD oil be taken with amitriptyline?
Mitch Kelley says:

February 28, 2019 at 11:06 pm

Dan, for a cbd product that even shows trace amounts of thc (.03%) yes it will show on a test. There is a patented cbd with .00 of thc so literally no thc and that one won’t show up!
Dan says:

January 19, 2019 at 4:36 pm

Is the small amount of THC THATS IN CBD oil detectitable in employment drug testing?
Nicholas says:

November 29, 2018 at 1:23 pm

Absolutely not… CBD products are an alternative to addictive prescriptions and other drugs that could cause harm to ones body and long term affects.
Nicole says:

September 10, 2018 at 5:33 pm

Is cbd addictive at all?